“The future of stem cell therapeutics relies on an intimate understanding of the transcriptional landscape that controls both the acquisition of ‘stemness’ and the controlled differentiation of embryonic stem cells and induced pluripotent stem cells”

You should prepare a case study of no more than 1500 words that explores the critical breakthroughs of Takahashi and Yamanaka and, using one example, delineates how the control of the transcriptional landscape permits reprogramming of stem cells for potential therapeutic benefit.