Fructose metabolism and its association with non-alcoholic fatty liver disease.

Read the following article regarding fructose metabolism and its association with non-alcoholic fatty liver disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663253/
How many adults does fatty liver disease affect in the western world?
What aspects of fructose metabolism may lead to fatty liver disease?
In human studies, the association between habitual consumption of high fructose diets and susceptibility to hepatic ATP depletion after an acute fructose challenge may be due to what compensatory mechanism?
Does recent literature suggest children with NAFLD are more sensitive to the adverse metabolic effects of fructose beverages than children without NAFLD? Please explain.
The authors estimate the amount of fructose consumed in the 1700’s versus present day levels. Describe this change in consumption and how it potentially relates to NAFLD as a public health crisis.
Thought question related to this article. Many countries consume diets high in carbohydrates such as rice (an
obvious paradox to the low carb diet craze) and have much lower rates of obesity than western countries.
Propose a reason(s) why rates of NAFLD are also not as high in these areas of the world. Think in terms of
how starch is digested and its carbohydrate building blocks.

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