Fixed costs and variable costs on a company's profitability

Company cost structure = total fixed costs plus total variable costs = total costs. Should a company cost structure contain a greater % of fixed costs (lesser
% variable costs) or vise versa?
In answering this question, discuss the advantages and disadvantages of fixed costs and variable costs on a company's profitability (cash flows) and risk.
You may also want to evaluate this question in terms of a company life cycle.