Copper is a component of numerous metalloenzymes and proteins that have a key role in maintaining the structure and function of the nervous system. It is a constituent of cytochrome oxidase (oxidative phosphorylation), superoxide dismutase (antioxidant defense), ceruloplasmin (iron metabolism), tyrosinase (melanin synthesis), and dopamine β-monooxygenase (catecholamine synthesis). Because of its wide distribution in foods and low daily requirement, a copper deficiency due to an inadequate diet is rare. An acquired copper deficiency can occur in adults however it is rare. in patients with malabsorption and nephrotic syndrome, and as a complication of zinc, penicillamine, and alkali therapy.
The paper discusses how rare copper myelopathy is. All resources must be in the last 5 years and only ncbi and in medical journals like JAMA and NEJM.