Biomarker Alzheimer’s disease: Alternatively consider multiple, neurodegenerative diseases
• Name of biomarker: Brain volume /ml

• Disease: Alzheimer’s disease: alternatively consider multiple, neurodegenerative diseases.

• Modality: In MRI

• Comment: could consider brain Subregions e.g. hippocampus

Report (including tables but excluding references and figures; figures to occupy no more than one page)
• What does the selected imaging biomarker purport to measure? (accurate reporting)
• How is it measured? (accurate reporting)
• How is it best classified? (accurate reporting)
• What are the key publications (reviews, meta- analyses, consensus guidelines etc) that describe the measurement and interpretation of this biomarker…
• …and what do they conclude? (accurate reporting)
• Clarity of writing and organization of material
• Professional standard of layout, formatting and citation