As we discussed in class, Aspirin inhibits cyclooxygenase-1 (COX-1) by irreversibly acetylating a serine
residue at position 529. It is also well-known that residue 523, an isoleucine - is a part of active site of
COX-1. In its isoform, COX-2, this residue is a valine. Explain how this information can be used to design a
molecule that can selectively bind to COX-2.